1018 Commensal microbiota regulates hair cycling by promoting dermal adipogenesis

Dermal white adipose tissue (dWAT) has been recently recognized as an indispensable deep skin layer with important non-metabolic functions in regulating hair cycling, wound regeneration, and defense against bacterial infection. We have previously shown that invasion to dermis triggers a reactive adipogenesis response, but whether commensal bacteria plays role dermal this cross-talk between dWAT is involved cycling not investigated. Here, by investigating germ-free mice and/or topical application of antibiotics, we found depletion microbiota led reduction the adipogenic potential fibroblasts, reduced volume, blockage depilation-induced onset cycling. Furthermore, intradermal injection conditioned medium from differentiating adipocytes restored neogenesis microbiota-depleted mice. Finally, showed products derived enhanced process was mediated myeloid differentiation factor 88 (Myd88), key adaptor signaling molecule downstream TLR pathway. Together, our results indicate may promote growth triggering through innate immune mechanism, be therapeutic for disorders characterized lipodystrophy follicle dysfunction.